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ASCO2009 膵臓がん演題リスト プリント メール
作者 Editor   
2009/06/08 Monday 08:27:19 JST

 ■米国臨床腫瘍学会2009(ASCO 2009 Abstract List)

 

 第45回米国臨床腫瘍学会(ASCO2009)は、5月29日から6月2日までの5日間にわたり開催された。膵臓がんに関連して74の演題が発表された。(Keyword: Panc) 

 

・術前術後療法については、7つの演題発表があり、フェーズ3は(5-FU/FA)対Gemの発表があった。

 

・局所進行がんについては、12の演題が発表され、フェーズ3は、TNFerade+CRTの中間発表があった。

 

・進行膵がんに関しては多数の発表があったが、そのなかでもフェーズ3については、

  ①Gem対Gem+Cisplatin、

  ②Gem+Erlotinib→Capecitabin対Capecitabin+Erlotinib→Gem(中間発表)

  ③CONKO004 Gem+Enoxaparin

 

の中間発表などがあった。

 

・腫瘍マーカーの発表では、膵上皮内がん(CIS)より以前の段階、膵がん前駆病変PanIN1から発見できるマーカーの開発、ステージ4患者の進行度評価、また、治療効果の予測に関するマーカーの開発など、ケア改善につながると期待される発表がみられた。

 

分類

演題数

術前・術後補助療法

局所進行膵癌

12

進行膵癌(1st Line)

32

進行膵癌(2nd Line)

免疫療法

治療効果・予後予測

10

腫瘍マーカー

研究

 




ABSTRACT TITLE

FIRST AUTHOR    

ABSTRACT NO.

The prognostic value of polymorphisms in the insulin-like growth factor receptor (IGFR) pathway in patients with locally advanced pancreatic cancer (LAPC). 予測因子・局所進行

R. T. Shroff

4500

A phase Ib study to evaluate the safety and efficacy of AMG 655 in combination with gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (PC).進行膵癌

H. L. Kindler

4501

A randomized trial of gemcitabine (G) versus G plus cisplatin in chemotherapy-naive advanced pancreatic adenocarcinoma: The GIP-1 (Gruppo Italiano Pancreas— GOIM/GISCAD/GOIRC) study.進行膵癌

G. Colucci

4504

ESPAC-3(v2): A multicenter, international, open-label, randomized, controlled phase III trial of adjuvant 5-fluorouracil/folinic acid (5-FU/FA) versus gemcitabine (GEM) in patients with resected pancreatic ductal adenocarcinoma. 術後補助

J. Neoptolemos

LBA4505

A prospective, randomized trial of chemotherapy with or without the low molecular weight heparin (LMWH) enoxaparin in patients (pts) with advanced pancreatic cancer (APC): Results of the CONKO 004 trial. 進行膵癌

H. Riess

LBA4506

SPARC correlation with response to gemcitabine (G) plus nab-paclitaxel (nab-P) in patients with advanced metastatic pancreatic cancer: A phase I/II study. 進行膵癌

D. D. Von Hoff

4525

Cationic liposomal paclitaxel in combination with gemcitabine in patients with advanced pancreatic cancer: A phase II trial.進行膵癌

M. Loehr

4526

Adjuvant gemcitabine alone versus gemcitabine-based chemoradiation after curative resection for pancreatic cancer: Updated results of a randomized EORTC/FFCD/GERCOR phase II study (40013-22012/9203).術後補助

J. L. Van Laethem

4527

Activity of gemcitabine in direct patient-derived xenografts and clinical outcome: Validation of an in vivo model for drug development. 研究

M. Hidalgo

4528

Integrated development of s-trans, trans-farnesylthiosalicyclic acid (FTS, salirasib) in advanced pancreatic cancer. 研究・進行膵癌

D. Laheru

4529

Heritable interleukin-17F (IL17F) gene variation and overall survival (OS) in pancreatic cancer patients (pts): Results from a genome-wide association study (GWAS) in CALGB 80303. 遺伝子研究

F. Innocenti

4531

Rash as a marker for the efficacy of gemcitabine plus erlotinib-based therapy in pancreatic cancer: Results from the AViTA Study. 進行膵癌(*)

C. Verslype

4532

A randomized phase III study of gemcitabine (G) versus GV1001 in sequential combination with G in patients with unresectable and metastatic pancreatic cancer (PC).進行膵癌

T. Buanes

4601

Phase I radiation dose-escalation trial of intensity-modulated radiotherapy (IMRT) with concurrent fixed dose-rate gemcitabine (FDR-G) for unresectable pancreatic cancer.切除不能

E. Ben-Josef

4602

Use of amolecular mimicry approach to identify effective agents in pancreatic cancer. 治療効果予測

A. Tan

4603

Gemcitabine plus erlotinib followed by capecitabine versus capecitabine plus erlotinib followed by gemcitabine: Interim toxicity analysis of a multicenter, randomized, cross-over phase III trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). 進行膵癌

V. Heinemann

4604

Multicenter randomized controlled phase III clinical trial using TNFerade (TNF) with chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC): Interim analysis (IA) of overall survival (OS).局所進行(*)

K. J. Chang

4605

A phase II trial of gemcitabine, docetaxel, and bevacizumab (GDB) in metastatic pancreas cancer.(進行膵癌)

V. J. Picozzi

4606

A phase II trial of erlotinib in combination with gemcitabine and capecitabine in previously untreated metastatic/recurrent pancreatic cancer: Combined analysis with translational research.(進行膵癌)

D. Oh

4607

A randomized phase II trial of adjuvant chemotherapy with cisplatin, epirubicin, 5-fluorouracil, gemcitabine (PEFG regimen) or gemcitabine alone after curative resection for pancreatic cancer. 術後補助

M. Reni

4608

Phase II trial of erlotinib in advanced pancreatic cancer (PC). 進行膵癌

P. Tang

4609

Final analysis of a multicenter, randomized phase II trial comparing three different chemoradiotherapy regimens in the treatment of patients with locally advanced, nonmetastatic pancreatic cancer. 局所進行

R. Wilkowski

4610

Use of a genome-wide association study to detect candidate polymorphisms associated with overall survival in stage IV pancreatic adenocarcinoma patients receiving gemcitabine monotherapy. 遺伝子・治療効果予測(進行膵癌)

H. Ueno

4611

Preclinical identification of biomarkers of response to mTOR inhibitors and subsequent application in a phase II trial of sirolimus in pancreatic cancer patients refractory to gemcitabine. 進行膵癌(*)

I. Garrido-Laguna

4612

Detection of early-stage pancreatic carcinoma. 早期発見

D. Gold

4613

A randomized phase II trial of two different four-drug combinations in advanced pancreatic adenocarcinoma: Cisplatin, capecitabine, gemcitabine plus either epirubicin or docetaxel. 進行膵癌(4剤)

S. Cereda

4614

Identification of prognostic factors for patients with advanced pancreatic cancer by proteomics. 進行膵癌(予後予測因子)

J. Matsubara

4615

GOFURTGO trial (GFG): An AGITG multicenter phase II study of fixed dose rate gemcitabine-oxaliplatin (Gem-Ox) integrated with concomitant 5FU and 3-D conformal radiotherapy (5FU-3DRT) for the treatment of locally advanced pancreatic cancer (LAPC). 進行膵癌

D. Goldstein

4616

Oral tyrosine kinase inhibitor masitinib in combination with gemcitabine in patients with advanced pancreatic cancer: A multicenter phase II study. 進行膵癌

P. Hammel

4617

A randomized phase II study of FOLFOX or FOLFIRI.3 as second-line therapy in patients with advanced pancreatic cancer previously treated with gemcitabine-based chemotherapy. 進行膵癌(2ndLine

J. Y. Hwang

4618

Interim results of the phase I/II study of trabedersen (AP 12009) in patients with pancreatic carcinoma, malignant melanoma, or colorectal carcinoma. 新薬治験

H. Oettle

4619

Multicenter study of radiosensitizing gemcitabine combined with fractionated radioimmunotherapy for repeated treatment cycles in advanced pancreatic cancer. 進行膵癌・放射線免疫療法

K. Pennington

4620

Inhibition of mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: The results of two prospective phase II studies. 進行膵癌

M. M. Javle

4621

Effects of adjuvant intra-operative radiation therapy after curative resection in pancreatic cancer patients : Results of a randomized study by 11 institutions in Japan.

術後補助

T. Kinoshita

4622

Phase II trial of GTX chemotherapy in metastatic pancreatic cancer. 進行膵癌

R. L. Fine

4623

Detection of circulating hypoxia-regulated miR-210 in pancreatic adenocarcinoma patients. 研究

A. S. Ho

4624

A phase II study of radiation and docetaxel and cisplatin in the treatment of locally advanced pancreatic carcinoma. FNCLCC-ACCORD 09 /0201 trial.局所進行

F. Viret

4625

Soluble iC3b as an early marker for pancreatic adenocarcinoma compared to CA 19.9 and radiology. 腫瘍マーカー

A. Marten

4626

E4201: Randomized phase II study of gemcitabine in combination with radiation therapy versus gemcitabine alone in patients with locally advanced, unresectable, pancreatic cancer (LAPC): Quality-of-life (QOL) analysis. 局所進行

H. R. Cardenes

4627

Salivary biomarkers for pancreatic cancer detection. 腫瘍マーカー

D. T. Wong

4630

A phase I study of gemcitabine plus dasatinib (GD) or gemcitabine plus dasatinib plus cetuximab (GDC) in refractory solid tumors.進行膵癌(2ndLine

H. E. Uronis

e15506

A phase II study of capecitabine (CAP) plus PHY906 in patients (pts) with advanced pancreatic cancer (APC). 進行膵癌

M. W. Saif

e15508

A multicenter randomized phase II study of full-dose gemcitabine and concurrent radiotherapy comparing gemcitabine alone for the unresectable locally advanced pancreatic adenocarcinoma. 局所進行

T. Ioka

e15512

Plasma IL-6 level and survival of pancreatic cancer patients treated with a VEGFR inhibitor, vatalanib (PTK/ZK). OS予測因子

A. F. Baker

e15514

Phase II capecitabine and gemcitabine fixed dose rate (FDR) in patients with advanced pancreatic cancer. 進行膵癌

G. Tonini

e15530

Phase I study of preoperative (pre-op) short course chemoradiation (CRT) with proton beam therapy (PBT) and capecitabine (cape) for resectable pancreatic ductal adenocarcinoma (PDAC) of the head. 術前補助

T. Hong

e15536

Clinical role of regulatory T cell in intraductal papillary mucinous neoplasms. IPMN免疫

Y. Morine

e15537

Phase I dose escalation study of pomalidomide in combination with gemcitabine in patients (pts) with untreated metastatic carcinoma of the pancreas. 進行膵癌

J. R. Infante

e15539

Application of a time-varying covariate model to the analysis of CA 19-9 as a biomarker for time-to-progression (TTP) and overall survival (OS) in patients with advanced pancreatic cancer.腫瘍マーカー

S. Boeck

e15545

Phase II trial of neoadjuvant fixed dose rate (FDR) gemcitabine with capecitabine (GX) combination chemotherapy in locally advanced pancreatic adenocarcinoma (LAPA). 術前療法

J. Lee

e15553

Definitive chemoradiation therapy with capecitabine in locally advanced pancreatic cancer. 局所進行

S. Yi

e15558

Phase II trial of second-line chemotherapy in metastatic pancreas cancer with the combination of oxaliplatin (Ox) and capecitabine (Cp). 進行膵癌(2ndLine)

J. Gasent Blesa

e15561

A phase II study of gemcitabine-based chemoradiotherapy (CCRT) after triplet induction chemotherapy (ICT) for locally advanced pancreatic cancer (LAPC): A Taiwan Cooperative Oncology Group (TCOG) study. 局所進行

H. Ch'ang

e15562

A retrospective analysis of tumor size (TS) as a continuous rather than discrete variable in advanced pancreatic cancer. 進行膵癌

N. C. Dhani

e15565

Pretreatment serum TIMP-1 levels and survival in advanced pancreatic cancer. 進行膵癌

R. Vargas

e15568

A phase II trial of oral fluoropyrimidine anticancer agent (S-1) with concurrent external-beam radiotherapy for locally advanced pancreatic cancer. 局所進行

H. Shinchi

e15570

Safety and efficacy of single-day GemOx (S-GemOx) regimen in pts with pancreatobiliary cancer (PBC). 局所進行

M. Y. Merl

e15577

Phase II study of gemcitabine chemotherapy alone for locally advanced pancreatic carcinoma: JCOG 0506.局所進行

H. Ishii

e15578

Impact of first-line and second-line PFS definitions within a randomized phase III trial in patients (pts) with metastatic pancreatic adenocarcinoma (MPA). 進行膵癌

L. Dahan

e15583

Association of gender, age, and ethnicity with survival in patients with pancreas cancer. 予後予測因子

M. Ottochian

e15587

Safety and tolerability of combined gemcitabine (G) and erlotinib (E) plus sorafenib (S) in the first-line treatment of metastatic pancreatic cancer. 進行膵癌(1stLine)

D. J. Cohen

e15594

Second-line pemetrexed-oxaliplatin combination for advanced pancreatic adenocarcinoma. 進行膵癌(2ndLine

M. Mazzer

e15597

A pilot phase I/II study of combination chemotherapy with nafamostat mesilate and gemcitabine for unresectable pancreatic cancer. 切除不能

T. Uwagawa

e15600

BRSK2 expression as a prognosis marker in pancreatic cancer patients. 予後因子

W. Lou

e15603

Identification of chromosomal regions that harbor novel genes important for pancreatic cancer pathogenesis by genome-wide screening methods. 遺伝子

S. Thieltges

e15609

KRAS mutations and relation to prognosis in patients operated for localized pancreatic cancer and other periampullary cancers. 予後因子・局所進行

N. A. Schultz

e15618

The analysis of EGFR expression and EGFR mutations in advanced pancreatic cancer. 進行膵癌

M. Ueno

e15629

A phase II study of Halichondrin B analog eribulin mesylate (E7389) as second-line therapy for patients with advanced pancreatic cancer.進行膵癌(2ndLine

M. J. Moore

e15634

The predictive role of CA 19-9 kinetics for time-to-progression (TTP) and overall survival (OS) in patients receiving palliative first-line chemotherapy for advanced pancreatic cancer. 予後予測

M. Haas

e15637

Effect of the serine proteases inhibitor gabexate mesylate (GM) on the activity of gemcitabine (G) in cell lines of pancreatic cancer (PC). 研究

G. Brandi

e15645

The role of S-1 in gemcitabine-refractory pancreatic cancer: A retrospective single-institution study. 進行膵癌(2ndLine)

Y. Nakai

e15648

Case study of a flexible bayesian design in a phase II study in patients with resected pancreas cancer. 臨床研究

F. E. Harrell

e15651

Therapeutic vaccination against advanced pancreatic cancer by autologous dendritic cells pulsed with a MUC1 peptide: Preclinical results of a clinical phase I trial. 免疫療法

D. Jin

e15652

Lapatinib and gemcitabine for metastatic pancreatic cancer: A phase II study. 進行膵癌

H. Safran

e15653

Prognostic relevance of ribonucleotide reductase small subunit p53R2 in pancreatic cancer 予後因子

V. M. Chung

e15655

Use of fermented mistletoe (viscum album L.) extract from oak tree (quercus) as supportive treatment for patients with pancreatic cancer. 補助療法

G. M. Stauder

e15656

Assessment of prognostic factors in pancreatic ductal adenocarcinoma: Focus on the retroperitoneal margin. 予後因子

A. M. Bellizzi

e15670

Preoperative gemcitabine based chemoradiotherapy in locally advanced nonmetastatic pancreatic adenocarcinoma. 術前補助

D. Maximous

e15677

Prevalence of depression, sleep-related disturbances, and anxiety and their effect on quality of life in patients with adenocarcinoma of the pancreas. 心のケア

D. Brown

e15678

Diagnostic yield of nonfunctional pancreatic neuroendocrine tumor using endoscopic ultrasound-guided fine needle aspiration biopsy. 内分泌腫瘍

K. Matsumoto

e15680

最終更新日 ( 2009/06/18 Thursday 14:53:37 JST )
 
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■米国臨床腫瘍学会2009(ASCO 2009 Abstract List)  第45回米国臨床腫瘍学会(ASCO2009)は、5月29日から6月2日までの5日間にわたり開催された。膵臓がんに関連して74の演題が発表された。(Keyword: Panc)  ・術前術後療法については、7つの演題発表があり、フェーズ3は(5-FU/FA)対Gemの発表があった。 ・局所進行がんについては、12の演題が発表され、フェーズ3は、TNFerade+CRTの中間発表があった。 ・進行膵がんに関しては多数の発表があったが、そのなかでもフェーズ3については、  ①Gem対Gem+Cisplatin、  ②Gem+Erlotinib→Capecitabin対Capecitabin+Erlotinib→Gem(中間発表)  ③CONKO004 Gem+Enoxaparin の中間発表などがあった。 ・腫瘍マーカーの発表では、膵上皮内がん(CIS)より以前の段階、膵がん前駆病変PanIN1から発見できるマーカーの開発、ステージ4患者の進行度評価、また、治療効果の予測に関するマーカーの開発など、ケア改善につながると期待される発表がみられた。 分類 演題数 術前・術後補助療法 7 局所進行膵癌 12 進行膵癌(1st Line) 32 進行膵癌(2nd Line) 3 免疫療法 2 治療効果・予後予測 10 腫瘍マーカー 4 研究 4